Research in the Dubnau lab

There are two major areas of research in the Dubnau Lab. First, we use the available toolbox for genetic manipulation in Drosophila melanogaster to uncover mechanistic underpinnings of memory using a Pavlovian olfactory task, with a strong emphasis on understanding the organization of neural circuits and the genes that function within them. The second major focus is to investigate a novel mechanism that we have proposed to underlie amyotrophic lateral sclerosis (ALS) and Frontotemporal lobar degeneration (FTLD). Our work on ALS/FTLD relies on a multidisciplinary approach that includes in vivo genetic experiments using mouse and Drosophila, experiments with post mortem human tissue, and cell culture assays.

"How to collect 60,000 fly heads"

"Training flies in the T-Maze"